Despite significant improvements in life expectancy for individuals with cystic fibrosis (CF) over the last two decades, CF continues to be a life-shortening disorder characterized by progressive, obstructive lung disease associated with chronic airway infection, inflammation, and parenchymal damage. Abnormal ion transport in the CF airways and altered antimicrobial airway defenses result in persistent infections with pathogens such as Pseudomonas aeruginosa. Although the progression of CF lung disease is impacted by many factors, P. aeruginosa infection is clearly associated with irreversible parenchymal damage and a sharper decline in lung function. Earlier age at first infection with P. aeruginosa has been associated with a 2.6 times higher risk of death [
], and repeated isolation of P. aeruginosa, or colonization, continues to be a major predictor of morbidity and mortality in people with CF.
- Emerson J
- Rosenfeld M
- McNamara S
- Ramsey B
- Gibson RL.
Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis.
Pediatr Pulmonol. 2002; 34: 91-100https://doi.org/10.1002/ppul.10127
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- Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis.Pediatr Pulmonol. 2002; 34: 91-100https://doi.org/10.1002/ppul.10127
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© 2023 Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.
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- Impact of antibiotic eradication therapy of Pseudomonas aeruginosa on long term lung function in cystic fibrosisJournal of Cystic FibrosisVol. 22Issue 1
- PreviewCystic fibrosis is a life-limiting autosomal recessive disorder with highest prevalence in Europe, North America and Australia . Around 30,000 individuals are affected in the United States and 45,000 in Europe . Over the last few decades, the median age of survival has increased substantially due to optimised treatment of secondary effects of CFTR dysfunction such as airway infection .