Highlights
- •Mothers of CRMS/CFSPID children had high rates of anxiety and depression.
- •Diagnosis had a negative impact while genetic counseling supported emotional health.
- •Mental health screening is recommended to mothers of CFSPID children.
Abstract
Objective
The purpose was to assess postpartum depression, anxiety, and depression in mothers
of children with an inconclusive diagnosis after a positive cystic fibrosis (CF) newborn
screening (NBS), known as cystic fibrosis transmembrane conductance regulator (CFTR)-related
metabolic syndrome (CRMS) or CF screen positive, inconclusive diagnosis (CFSPID).
There is limited information on the prognosis and on the impact of this designation
on maternal mental health.
Methods
Mothers of children with CRMS/CFSPID and CF identified by NBS were recruited from
two centers in California. Maternal mental health was assessed using measures of depression,
anxiety, and a scripted interview. Descriptive statistics and multivariate logistic
regression were applied for data reporting.
Results
A total of 109 mothers were recruited: CF: 51, CRMS/CFSPID: 58. Mothers from both
groups showed higher rates of depression and anxiety symptoms than women in the general
population. CRMS/CFSPID and CF mothers had no significant difference on their self-reported
symptoms of anxiety and depression after adjusting for potential confounders. Mothers
equally reported that their child's diagnosis had a negative impact, and that genetic
counseling had a positive impact on their emotional health.
Conclusions
CF and CRMS/CFSPID diagnoses impact maternal mental health similarly. Uncertain prognosis
of CRMS/CFSPID likely contributed to the negative mental health impact. Providers
should consider conducting mental health screening for every mother of a child with
CRMS/CFSPID, in addition to the recommended mental health screening for mothers of
children with CF. Genetic counseling has potential to mitigate emotional stress on
these families.
Keywords
Abbreviations:
CF (cystic fibrosis), CFSPID (cystic fibrosis screen positive, inconclusive diagnosis), CFTR (cystic fibrosis transmembrane conductance regulator), CHLA (Children's Hospital Los Angeles), CRMS (cystic fibrosis transmembrane conductance regulator-related metabolic syndrome), EPDS (Edinburgh Postpartum Depression Scale), GAD – 7 (Generalized Anxiety Disorder – 7), HIPAA (Health Insurance Portability and Accountability Act), HMO (Health Maintenance Organization), IRT (immunoreactive trypsinogen), NBS (newborn screening), PHQ – 8 (Patient Health Questionnaire – 8)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 16, 2022
Accepted:
December 5,
2022
Received in revised form:
November 28,
2022
Received:
June 13,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
