Despite improvements in survival from cystic fibrosis (CF) over successive decades,
many infants with CF have diminished lung function within months of being diagnosed
on newborn screening [
[1]
,
[2]
]. Early childhood has been identified as a crucial period in the establishment of
future lung disease. However, the age of onset and progression of CF lung disease
is highly variable, creating uncertainty as to how proactively children should be
monitored and treated. Reducing the burden of daily treatments is a priority for the
CF community [
[3]
], especially as the use of highly effective modulator therapies becomes widespread.
There is therefore a need to identify children at high risk of irreversible lung damage
who would benefit most from intensive management strategies. In this issue of the
Journal, research groups from both the UK and Australia report prospective observational
data investigating early life factors associated with loss of lung function at different
periods in childhood.- Bayfield K.J.
- Douglas T.A.
- Rosenow T.
- Davies J.C.
- Elborn S.J.
- Mall M.
- Paproki A.
- Ratjen F.
- Sly P.D.
- Smyth A.R.
- Stick S.
- Wainwright C.E.
- Robinson P.D.
Time to get serious about the detection and monitoring of early lung disease in cystic
fibrosis.
ThoraxThorax. 2021; ([Internet] BMJ Publishing Group Ltd[cited 2021 Apr 30];: thoraxjnl-2020-216085Available
from)
Abbreviations:
LCFC (London Cystic Fibrosis Collaboration), ACFBAL (Australasian Cystic Fibrosis Bronchoalveolar Lavage), BAL (bronchoalveolar lavage), PsA (Pseudomonas aeruginosa), AREST-CF (Australian Respiratory Early Surveillance Team for Cystic Fibrosis)To read this article in full you will need to make a payment
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References
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- Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis.ThoraxThorax. 2021; ([Internet] BMJ Publishing Group Ltd[cited 2021 Apr 30];: thoraxjnl-2020-216085Available from)
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Article info
Publication history
Published online: August 29, 2022
Accepted:
August 25,
2022
Received:
August 24,
2022
Identification
Copyright
© 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
