Time to change course and tackle CF related obesity

Published:August 12, 2022DOI:
      Poor nutrition in people with Cystic Fibrosis (CF) is associated with poor clinical outcomes and early intervention is essential for normal growth, development and to ensure clinical stability. Over the past few decades, the nutritional status and survival of people with CF (pwCF) has dramatically improved, a far cry from the early descriptions of CF in the 1930s, where malnutrition was a distinctive feature and life expectancy was limited to early childhood [
      • Andersen D.
      Cystic fibrosis of the pancreas and its relation to celiac disease - A clinical and pathologic study.
      ]. Inadvertently, the pendulum has swung the other way, and resulted in an increase prevalence of overweight and obese individuals with CF. These changes have developed over several decades [
      • Peckham D.
      • Whitaker P.
      Drug induced complications; can we do more?.
      ] and been further augmented by the introduction of highly effective CFTR modulators.
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