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Obesity in Cystic fibrosis: prevalence, trends and associated factors data from the US cystic fibrosis foundation patient registry

Published:April 05, 2022DOI:https://doi.org/10.1016/j.jcf.2022.03.010

      Highlights

      • Trends in increasing BMI across CF centers suggest significantly increasing proportions of overweight and obese status in recent years.
      • Between 2000 and 2019 there has been a relative decrease in underweight status by ∼40%, simultaneously with a > 300% increase in overweight status, and >400% increase in obesity.
      • Patient specific factors associated with higher prevalence of obesity included older age, having at least one allele with a class IV or V mutation, modulator access and pancreatic sufficiency.
      • The adverse sequelae of obesity should also be considered within this population in the future.

      Abstract

      Strong emphasis has been placed historically on increasing weight and improving nutritional status in cystic fibrosis patients. Due to correlation between nutritional indices (e.g. BMI) and lung function, CF Nutrition Guidelines have recommended BMI percentile goals at the 50th percentile or higher. Trends in increasing BMI across CF programs suggest significantly increasing proportions of overweight and obese status in recent years. We identify that between 2000 and 2019 there has been a relative decrease in underweight status by ∼40%, simultaneously with a > 300% increase in overweight status, and >400% increase in obesity. Patient specific factors associated with higher prevalence of obesity included age ≥46, living in a zip code where the median income was < $20,000, having at least one allele with a class IV or V mutation, a ppFEV1 >90 prescribed ivacaftor, and not prescribed pancreatic enzymes. Program specific factors were not identified.

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