Highlights
- •Historic cohorts suggested that supply of inhaled medicines may exceed actual use.
- •This is the first study to directly compare medicine supply (MPR) against adherence.
- •Among 275 adults in 12 CF centres, MPR over-estimates adherence by a median of 14%.
- •Even with 20% contingency, mean annual cost of excess supply was £1,124/patient.
- •Excess supply cost was higher in those with adherence <50% (mean £2,017/patient).
Abstract
Background
Methods
Results
Conclusions
Keywords
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- Corrigendum to “Using a learning health system to understand the mismatch between medicines supply and actual medicines use among adults with cystic fibrosis” [J Cyst Fibros (2022), 21/2, 323-331]Journal of Cystic FibrosisVol. 21Issue 5
- PreviewThe authors regret an error has occurred in the description and calculation of dose-weighted composite MPR (dwcMPR) for participants on multiple medicines. We described dose-weighting according to the number of dispensed inhaled medications. In fact, the dose-weighting should be based on the number of prescribed inhaled medications to ensure there is no gap between the cMPR and electronic data capture (EDC) adherence if someone has indeed used all the medicines that were supplied. Therefore, the first step to calculate dwcMPR should have been: calculate the total prescribed doses of medicine by adding up of all individual values of daily prescribed dose × days.
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