Journal of Cystic Fibrosis
Volume 10, Supplement 2 , Pages S146-S151, June 2011

Antibiotic treatment of CF lung disease: From bench to bedside

  • Robert Bals

      Affiliations

    • Klinik für Innere Medizin V, Pneumologie, Allergologie und Respiratorische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
    • Corresponding Author InformationCorresponding author: Robert Bals, MD, PhD, Department of Internal Medicine V – Pulmonary Diseases, University Hospital of the Saarland, Kirrbergerstr. 1, D-66421 Homburg, Germany. Tel.: +49 6841 16 23601; fax: +49 6841 16 23602
    • ,
  • Dominique Hubert

      Affiliations

    • CRCM – Service de Pneumologie – Hôpital Cochin, Assistance Publique des Hôpitaux de Paris, F-75679 Paris Cedex 14, France
    • ,
  • Burkhard Tümmler

      Affiliations

    • Klinische Forschergruppe, Abteilung für Pädiatrische Pneumologie und Neonatologie, OE 6710, Medizinische Hochschule Hannover, D-30625 Hannover, Germany

Abstract 

Chronic infection of the respiratory tract is a hallmark of cystic fibrosis (CF). Antibiotic treatment has been used as one of the mainstays of therapy and together with other treatment modalities has resulted in increased survival of CF patients. Increasing resistance of CF-specific pathogens to various classes of antibiotics explains the need for novel antibiotic strategies. This review focuses on the future development of new antibiotic therapies, including: (1) New targets, (2) novel antibiotic regimens in CF, (3) new antibiotics, and (4) other investigational therapies. In addition, we briefly summarize developments in the area of microbial diagnostics and discuss interactions between the complex pulmonary microflora.

Keywords:  Antimicrobial treatment , Drug development , Microbiome , Susceptibility testing

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PII: S1569-1993(11)60019-2

doi:10.1016/S1569-1993(11)60019-2

Journal of Cystic Fibrosis
Volume 10, Supplement 2 , Pages S146-S151, June 2011

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