Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 277-279 , July 2010

Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways

  • Hans-Peter Hauber

      Affiliations

    • Division of Pathophysiology of Inflammation, Research Center Borstel, Borstel, Germany
    • Meakins-Christie Laboratories, McGill University, Montreal, Canada
    • Corresponding Author InformationCorresponding author. Division of Pathophysiology of Inflammation, Research Center Borstel, Parkallee 35, 23845 Borstel, Germany. Tel.: +49 4537 188 364; fax: +49 4573 188 313.
    • ,
  • Francois Lavigne

      Affiliations

    • Meakins-Christie Laboratories, McGill University, Montreal, Canada
    • ,
  • Hsiao-Ling Hung

      Affiliations

    • Genaera Corporation, Plymouth Meeting, PA, USA
    • ,
  • Roy C. Levitt

      Affiliations

    • Genaera Corporation, Plymouth Meeting, PA, USA
    • ,
  • Qutayba Hamid

      Affiliations

    • Meakins-Christie Laboratories, McGill University, Montreal, Canada

Received 28 March 2010 ,Revised 3 May 2010 ,Accepted 5 May 2010.

References 

  1. Evans CM, Koo JS. Airway mucus: the good, the bad, the sticky. Pharmacol Ther. 2009;121:32–348
  2. Voynow JA. L, Wang Y, Horger T, Rose MC, Fischer BM. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol. 1999;276:L835–L843
  3. Li JD, Dohrman AF, Gallup M, et al. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA. 1997;94:967–972
  4. Hauber HP, Tsicopoulos A, Wallaert B, et al. Expression of hCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur Respir J. 2004;23:846–850
  5. Moser C, Kjaergaard S, Pressler T, Kharazmi A, Koch C, Hoiby N. The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type. APMIS. 2000;108:329–335
  6. Hartl D, Griese M, Kappler M, et al. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J Allergy Clin Immunol. 2006;117:204–211
  7. Wojnarowski C, Frischer T, Hofbauer E, et al. Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation. Eur Respir J. 1999;14:1136–1144
  8. Hauber HP, Gholami D, Koppermann G, Heuer HE, Meyer A, Pforte A. Increased expression of interleukin-13 but not interleukin-4 in cystic fibrosis patients. J Cyst Fibros. 2003;2:189–194
  9. Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol. 1999;162:6233–6237
  10. Louahed J, Toda M, Jen J, et al. Interleukin-9 upregulates mucus expression in the airways. Am J Respir Cell Mol Biol. 2000;22:649–656
  11. Whittaker L, Niu N, Temann UA, et al. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol. 2002;27:593–602
  12. Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285(3):L730–L739
  13. Groneberg DA, Peiser C, Dinh QT, et al. Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope. 2003;113:520–524
  14. Dandurand RJ, Wang CG, Laberge S, Martin JG, Eidelman DH. In vitro allergic bronchoconstriction in the Brown Norway rat. Am J Respir Crit Care Med. 1994;149:1499–1505
  15. Zhou Y, Dong Q, Louahed J, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol. 2001;25:486–491
  16. Loewen ME, Forsyth GW. Structure and function of CLCA proteins. Physiol Rev. 2005;85:1061–1092
  17. Hauber HP, Goldmann T, Vollmer E, et al. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors. J Endotoxin Res. 2007;13:109–116
  18. Hauber HP, Steffen A, Goldmann T, et al. Effect of steroids, acetyl-cystein and calcium-activated chloride channel inhibitors on allergic mucin expression in sinus mucosa. Laryngoscope. 2008;118:1528–1533

PII: S1569-1993(10)00067-6

doi: 10.1016/j.jcf.2010.05.002

Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 277-279 , July 2010

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