Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 257-262 , July 2010

Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis

  • Hanne Vebert Olesen

      Affiliations

    • Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Århus N, Denmark
    • Corresponding Author InformationCorresponding author. Pediatric Department A Aarhus University Hospital Skejby 8200 Aarhus N, Denmark. Tel.: +45 89 49 67 40; fax: + 45 89 49 60 23.
    • ,
  • Uffe Holmskov

      Affiliations

    • Medical Biotechnology Center, University of Southern Denmark, 5230 Odense M, Denmark
    • ,
  • Peter Oluf Schiøtz

      Affiliations

    • Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Århus N, Denmark
    • ,
  • Grith Lykke Sørensen

      Affiliations

    • Medical Biotechnology Center, University of Southern Denmark, 5230 Odense M, Denmark

Received 31 January 2010 ,Revised 22 March 2010 ,Accepted 29 March 2010.

References 

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  2. Bufler P, Schmidt B, Schikor D, Bauernfeind A, Crouch EC, Griese M. Surfactant protein A and D differently regulate the immune response to nonmucoid Pseudomonas aeruginosa and its lipopolysaccharide. Am J Respir Cell Mol Biol. 2003 Feb;28(2):249–256
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  10. Sin DD, Leung R, Gan WQ, Man SP. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med. 2007;7:13
  11. Lomas DA, Silverman EK, Edwards LD, Locantora NW, Miller BE, Horstman DH, et al. Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J. 2009;34:95–102
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  14. Heidinger K, Konig IR, Bohnert A, Kleinsteiber A, Hilgendorff A, Gortner L, et al. Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced. Immunogenetics. 2005 Apr;57(1–2):1–7
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  21. Griese M, Essl R, Schmidt R, Rietschel E, Ratjen F, Ballmann M, et al. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000–1005
  22. Henderson NG, Postle AD, George D. Proteolysis of surfactant protein D (SP-D) in children with CF. J Cyst Fibros. 2004;3(Suppl 2):S23;Ref Type: Abstract
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PII: S1569-1993(10)00038-X

doi: 10.1016/j.jcf.2010.03.011

Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 257-262 , July 2010

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