Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 272-276, July 2010

Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection☆

  • Marita Gilljam

      Affiliations

    • Department of Respiratory Medicine and Allergology, Bruna Stråket 11b, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 31 3421000/+46 31 3427867; fax: +46 31824904.
    • ,
  • Henrik Scherstén

      Affiliations

    • Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    • ,
  • Martin Silverborn

      Affiliations

    • Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    • ,
  • Bodil Jönsson

      Affiliations

    • Department of Clinical Bacteriology, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    • ,
  • Annika Ericsson Hollsing

      Affiliations

    • Department of Pediatrics, Uppsala Academic Hospital, SE 751 85 Uppsala, Sweden

Received 1 January 2010; received in revised form 14 March 2010; accepted 15 March 2010.

Abstract 

Mycobacterium abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with recent treatment for Mycobacterium abscessus lung infection. Despite prolonged antibiotic courses and adjustment of immunosuppressive therapy the first three patients developed skin infection and abscesses. At follow-up after 1, 3, 5 and 7years respectively no patient had evidence of M abscessus infection and all had stable lung function. Lung transplantation in patients with M abscessus lung infection is feasible but may involve severe complications.

Keywords: Cystic fibrosis, Lung transplantation, Mycobacterium, Complication, Abscess

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☆ This work has in part been presented at the 32nd European Cystic Fibrosis Conference, Brest, France, 2009.

PII: S1569-1993(10)00035-4

doi:10.1016/j.jcf.2010.03.008

Journal of Cystic Fibrosis
Volume 9, Issue 4 , Pages 272-276, July 2010

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