Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 130-134 , March 2010

Upper and lower airway cultures in children with cystic fibrosis: Do not neglect the upper airways

Received 5 October 2009 ,Revised 23 December 2009 ,Accepted 4 January 2010.

References 

  1. Menzin J, Oster G, Davies L, et al. A multinational economic evaluation of rhDNase in the treatment of cystic fibrosis. Int J Technol Assess Health Care. 1996;12:52–61
  2. Robertson JM, Friedman EM, Rubin BK. Nasal and sinus disease in cystic fibrosis. Paediatr Respir Rev. 2008;9:213–219
  3. Hurst JR, Wilkinson TM, Perera WR, Donaldson GC, Wedzicha JA. Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPD. Chest. 2005;127:1219–1226
  4. Roberts NJ, Lloyd-Owen SJ, Rapado F, et al. Relationship between chronic nasal and respiratory symptoms in patients with COPD. Respir Med. 2003;97:909–914
  5. Taccetti G, Campana S, Festini F, Mascherini M, Doring G. Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients. Eur Respir J. 2005;26:458–461
  6. Taylor CJ, McGaw J, Howden R, Duerden BI, Baxter PS. Bacterial reservoirs in cystic fibrosis. Arch Dis Child. 1990;65:175–177
  7. Mainz JG, Naehrlich L, Schien M, et al. Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis. Thorax. 2009;
  8. Ratjen F, Walter H, Haug M, Meisner C, Grasemann H, Doring G. Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients. Pediatr Pulmonol. 2007;42:249–255
  9. da Silva Filho LV, Tateno AF, Martins KM, et al. The combination of PCR and serology increases the diagnosis of Pseudomonas aeruginosa colonization/infection in cystic fibrosis. Pediatr Pulmonol. 2007;42:938–944
  10. Arets HG, Brackel HJ, van der Ent CK. Forced expiratory manoeuvres in children: do they meet ATS and ERS criteria for spirometry?. Eur Respir J. 2001;18:655–660
  11. Zapletal A, Chalupova J. Forced expiratory parameters in healthy preschool children (3–6years of age). Pediatr Pulmonol. 2003;35:200–207
  12. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl. 1993;16:5–40
  13. Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros. 2003;2:29–34
  14. Ramsey BW, Wentz KR, Smith AL, et al. Predictive value of oropharyngeal cultures for identifying lower airway bacteria in cystic fibrosis patients. Am Rev Respir Dis. 1991;144:331–337
  15. Armstrong DS, Grimwood K, Carlin JB, Carzino R, Olinsky A, Phelan PD. Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis. Pediatr Pulmonol. 1996;21:267–275
  16. Franche GL, Abreu e Silva , Saleh CS. Bacteriology of the middle meatus aspirate in patients with cystic fibrosis. Braz J Otorhinolaryngol. 2007;73:494–499
  17. Drake-Lee AB, Morgan DW. Nasal polyps and sinusitis in children with cystic fibrosis. J Laryngol Otol. 1989;103:753–755
  18. Muhlebach MS, Miller MB, Moore C, Wedd JP, Drake AF, Leigh MW. Are lower airway or throat cultures predictive of sinus bacteriology in cystic fibrosis?. Pediatr Pulmonol. 2006;41:445–451
  19. Dosanjh A, Lakhani S, Elashoff D, Chin C, Hsu V, Hilman B. A comparison of microbiologic flora of the sinuses and airway among cystic fibrosis patients with maxillary antrostomies. Pediatr Transplant. 2000;4:182–185
  20. Jung A, Kleinau I, Schonian G, et al. Sequential genotyping of Pseudomonas aeruginosa from upper and lower airways of cystic fibrosis patients. Eur Respir J. 2002;20:1457–1463
  21. Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol. 2002;34:91–100
  22. Nixon GM, Armstrong DS, Carzino R, et al. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr. 2001;138:699–704
  23. Pamukcu A, Bush A, Buchdahl R. Effects of Pseudomonas aeruginosa colonization on lung function and anthropometric variables in children with cystic fibrosis. Pediatr Pulmonol. 1995;19:10–15
  24. Walter S, Gudowius P, Bosshammer J, et al. Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis. Thorax. 1997;52:318–321
  25. Ratjen F, Stenglein S, Munck A. Inhaled tobramycin nebulizer solution for treatment of early Pseudomonas aeruginosa infection: the ELITE study. J Cyst Fibrosis. 2008;7:S26;(abstr)

PII: S1569-1993(10)00005-6

doi: 10.1016/j.jcf.2010.01.001

Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 130-134 , March 2010