What is the best method for measuring renal function in adults and children with cystic fibrosis?

Soulsby, Natalie; Greville, Hugh; Coulthard, Kingsley; Doecke, Chris

doi:10.1016/j.jcf.2009.12.002

« Previous Next »Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 124-129, March 2010

What is the best method for measuring renal function in adults and children with cystic fibrosis?☆

Natalie Soulsby
- Sansom Institute, University of South Australia, Frome Road, Adelaide SA 5001, Australia
- Department of Pharmacy, Women's and Children's Hospital, King William Road, North Adelaide, SA 5006, Australia
- Department of Pharmacy, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
- Corresponding author. Sansom Institute, University of South Australia, Frome Road, Adelaide SA 5001, Australia. Fax: +61 8 8302.
Hugh Greville
- Department of Thoracic Medicine, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
Kingsley Coulthard
- Sansom Institute, University of South Australia, Frome Road, Adelaide SA 5001, Australia
- Department of Pharmacy, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
Chris Doecke
- Sansom Institute, University of South Australia, Frome Road, Adelaide SA 5001, Australia
- Department of Pharmacy, Women's and Children's Hospital, King William Road, North Adelaide, SA 5006, Australia

Received 1 October 2009; received in revised form 4 December 2009; accepted 23 December 2009.

Abstract

AIMS

To measure the glomerular filtration rate (GFR) in adults and children with cystic fibrosis (CF) using a radio-isotope technique as the gold standard and to compare this to serum creatinine based equations, serum cystatin C levels and tobramycin clearance, and to determine which method correlates most closely with measured GFR in this population.