Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 93-98 , March 2010

Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis

  • Elizabeth F. Shead

      Affiliations

    • Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • Charles S. Haworth

      Affiliations

    • Adult Cystic Fibrosis Centre, Papworth Hospital, Cambridge, UK
    • ,
  • Helen Barker

      Affiliations

    • Adult Cystic Fibrosis Centre, Papworth Hospital, Cambridge, UK
    • ,
  • Diana Bilton

      Affiliations

    • Department of Cystic Fibrosis, Royal Brompton Hospital, London, UK
    • ,
  • Juliet E. Compston

      Affiliations

    • Department of Medicine, University of Cambridge, Cambridge, UK
    • Corresponding Author InformationCorresponding author.

Received 21 September 2009 ,Revised 19 November 2009 ,Accepted 23 November 2009.

References 

  1. Haworth C, Selby P, Webb A, Dodd M, Musson H, McL Niven R, et al. Low bone mineral density in adults with cystic fibrosis. Thorax. 1999;54(11):961–967
  2. Conway S, Morton A, Oldroyd B, Truscott J, White H, Smith B, et al. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax. 2000;55(9):798–804
  3. Elkin S, Fairney A, Burnett S, Kemp M, Kyd P, Burgess J, et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int. 2001;12(5):366–372
  4. Aris RM, Winders AD, Buell HE, Riggs DB, Lester GE, Ontjes DA. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med. 1998;128(3):186–193
  5. Ott SM. Osteoporosis in patients with cystic fibrosis. Clin Chest Med. 1998;19(3):555–567
  6. Aris R, Guise TA. Cystic fibrosis and bone disease: are we missing a genetic link?. Europ Resp J. 2005;25(1):9–11
  7. Aris R, Stephens A, Ontjes D, Denene Blackwood A, Lark R, Hensler M, et al. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med. 2000;162(5):1674–1678
  8. Ionescu A, Nixon L, Evans W, Stone M, Lewis-Jenkins V, Chatham K, et al. Bone density, body composition, and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med. 2000;162(3):789–794
  9. Shead E, Haworth CS, Gunn E, Bilton D, Scott MA, Compston JE. Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis. Am J Crit Care Med. 2006;174(3):306–311
  10. Saidenberg-Kermanach N, Bessis N, Cohen-Solal M, De Vernejoul MC, Boissier MC. Osteoprotegerin and inflammation. Eur Cytokine Netw. 2002;13(2):144–153
  11. Tanaka Y, Nakayamada S, Okada Y. Osteoblasts and osteoclasts in bone remodelling and inflammation. Curr Drug Targets Inflamm Allergy. 2005;4(3):325–328
  12. Xing L, Schwarz EM, Boyce BF. Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev. 2005;208:19–29
  13. Clowes J, Riggs BL, Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev. 2005;208:207–227
  14. Walsh N, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005;208:228–251
  15. O'Gradaigh D, Bord S, Ireland D, Compston JE. Osteoclastic bone resorption in rheumatoid arthritis and the acute-phase response. Rheumatol. 2003;41(11):1429–1430
  16. Walsh N, Gravallese EM. Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004;16(4):419–427
  17. Ehrlich L, Roodman GD. The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma. Immunol Rev. 2005;208:252–266
  18. Graves D, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol. 2003;74(3):391–401
  19. Moschen AR, Kaser A, Enrich B, Ludwiczek O, Gabriel M, Obrist P, et al. The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss. Gut. 2005;54(4):479–487
  20. Vestergaard P. Prevalence and pathogenesis of osteoporosis in patients with inflammatory bowel disease. Minerva Med. 2004;95(6):469–480
  21. Conway S. Impact of lung inflammation on bone metabolism in adolescents with cystic fibrosis. Paed Resp Rev. 2001;2(4):324–331
  22. Bell S, Bowerman AM, Nixon LE, Macdonald IA, Elborn JS, Shale DJ. Metabolic and inflammatory responses to pulmonary exacerbation in adults with cystic fibrosis. Eur J Clin Invest. 2000;30:553–559
  23. Haworth C, Selby P, Webb A, L. M, JS. E, Sharples L, et al. Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax. 2004;59(7):613–617
  24. Fuchs H, Borowitz DS, Christiansen DH. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med. 1994;331:637–642
  25. Beeton CA, Bord S, Ireland D, Compston JE. Osteoclast formation and bone resorption are inhibited by megakaryocytes. Bone. 2006;39(5):985–990
  26. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473:139–146
  27. Jorgensen L, Skjelbakken T, Lochen ML, Ahmed L, Bjornerem A, Joakimsen R, et al. Anemia and the risk of non-vertebral fractures: the Tromso Study. Osteoporos Int 2009 Dec 3 (Electronic publication ahead of print).
  28. Elkin S, Vedi S, Bord S, Garrahan NJ, Hodson ME, Compston JE. Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am J Respir Crit Care Med. 2002;166(11):1470–1474
  29. Perry MG, Kirwan JR, Jessop DS, Hunt LP. Overnight variations in cortisol, interleukin 6, tumour necrosis factor a and other cytokines in people with rheumatoid arthritis. Ann Rheum Dis. 2009;68:63–68
  30. Shimizu M, Onoe Y, Mikumo MH, Miyabara Y, Kuroda T, Yoshikata R, et al. Variations in circulating osteoprotegerin and soluble RANKL during diurnal and menstrual cycles in young women. Horm Res. 2009;71:285–289

PII: S1569-1993(09)00154-4

doi: 10.1016/j.jcf.2009.11.007

Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 93-98 , March 2010

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