Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 99-103 , March 2010

Genotype based evaluation of Pseudomonas aeruginosa eradication treatment success in cystic fibrosis patients

  • Petra Schelstraete

      Affiliations

    • Cystic Fibrosis Center Gent, Ghent University Hospital, 9000 Gent, Belgium
    • Corresponding Author InformationCorresponding author. Pediatric Pulmonology and Cystic Fibrosis Clinic, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. Tel.: +32 9 332 2852; fax: +32 9 332 3861.
    • These authors contributed equally in this article.
    • ,
  • Pieter Deschaght

      Affiliations

    • Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, 9000 Gent, Belgium
    • These authors contributed equally in this article.
    • Pieter Deschaght is indebted to the IWT for PhD research grant IWT-SB/71184.
    • ,
  • Leen Van Simaey

      Affiliations

    • Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, 9000 Gent, Belgium
    • ,
  • Sabine Van daele

      Affiliations

    • Cystic Fibrosis Center Gent, Ghent University Hospital, 9000 Gent, Belgium
    • ,
  • Filomeen Haerynck

      Affiliations

    • Cystic Fibrosis Center Gent, Ghent University Hospital, 9000 Gent, Belgium
    • ,
  • Mario Vaneechoutte

      Affiliations

    • Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, 9000 Gent, Belgium
    • ,
  • Frans De Baets

      Affiliations

    • Cystic Fibrosis Center Gent, Ghent University Hospital, 9000 Gent, Belgium

Received 28 September 2009 ,Revised 20 November 2009 ,Accepted 23 November 2009.

References 

  1. Means MB, Hunt GH, Rushworth R. Bacterial flora of respiratory tract in patients with cystic fibrosis, 1950–71. Arch Dis Child. 1972;47:902–907
  2. Høiby N. Epidemiological investigations of the respiratory tract bacteriology in patients with cystic fibrosis. Acta Pathol Microbiol Scand [B] Microbiol Immunol. 1974;82:541–550
  3. FitzSimmons S. The cystic fibrosis patient registry report. Pediatr Pulmonol. 1996;21:267–275
  4. Kosorok MR, Zeng L, West SE, Rock MJ, Splaingard ML, Laxova A, et al. Acceleration of lung disease in children with cystic fibrosis after Pseudomonas aeruginosa acquisition. Pediatr Pulmonol. 2001;32:277–287
  5. Nixon GM, Armstrong DS, Carzino R, Carlin JB, Olinsky A, Robertson CF, et al. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr. 2001;138:699–704
  6. Kerem E, Corey M, Gold R, Levison H. Pulmonary function and clinical course in patients with cystic fibrosis after pulmonary colonization with Pseudomonas aeruginosa. J Pediatr. 1990;116:714–719
  7. Henry RL, Mellis CM, Petrovic L. Mucoid Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosis. Pediatr Pulmonol. 1992;12:158–161
  8. Fitzsimmons S. The changing epidemiology of cystic fibrosis. J Pediatr. 1993;122:1–9
  9. Valerius NH, Koch C, Høiby N. Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment. Lancet. 1991;338:725–726
  10. Vasquez C, Municio M, Corera M, Gaztelurrutia L, Sojo A, Vitoria JC. Early treatment of Pseudomonas aeruginosa colonisation in cystic fibrosis. Acta Paediatr Scand. 1993;82:308–309
  11. Frederiksen B, Koch C, Høiby N. Changing epidemiology of Pseudomonas aeruginosa infection in Danish cystic fibrosis patients. Pediatr Pulmonol. 1999;28:159–166
  12. Frederiksen B, Koch C, Høiby N. Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol. 1997;23:330–335
  13. Jones AM, Dodd ME, Govan JR, Doherty CJ, Smith CM, Isalska BJ, et al. Prospective surveillance for Pseudomonas aeruginosa cross-infection at a cystic fibrosis center. Am J Respir Crit Care Med. 2005;171:257–260
  14. Scott FW, Pitt TL. Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J Med Microbiol. 2004;53:609–615
  15. Van daele S, Vaneechoutte M, De Boeck K, Knoop C, Malfroot A, Lebecque P, et al. Survey of Pseudomonas aeruginosa genotypes in colonised cystic fibrosis patients. Eur Respir J. 2006;28:740–747
  16. Munck A, Bonacorsi S, Mariani-Kurkdjian P, Lebourgeois M, Gérardin M, Brahimi N, et al. Genotypic characterization of Pseudomonas aeruginosa strains recovered from patients with cystic fibrosis after initial and subsequent colonization. Pediatr Pulmonol. 2001;32:288–292
  17. Taccetti G, Campana S, Festini F, Mascherini M, Döring G. Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients. Eur Respir J. 2005;26:458–461
  18. Hansen CR, Pressler T, Høiby N. Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15years experience. J Cyst Fibros. 2008;7:523–530
  19. Döring G, Høiby N for the Consensus Study Group. Early intervention and prevention of lung disease in cystic fibrosis: a European consensus. J Cyst Fibros. 2004;3:67–91
  20. Döring G, Conway SP, Heijerman HG, Hodson ME, Høiby N, Smyth A, et al. Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. Eur Respir J. 2000;16:749–767
  21. Vaneechoutte M, Boerlin P, Tichy HV, Bannerman E, Jager B, Bille J. Comparison of PCR-based DNA fingerprinting techniques for the identification of Listeria species and their use for atypical Listeria isolates. Int J Syst Bacteriol. 1998;48:127–139
  22. Baele M, Baele P, Vaneechoutte M, Storms V, Butaye P, Devriese LA, et al. Application of tRNA intergenic spacer PCR for identification of Enterococcus species. J Clin Microbiol. 2000;38:4201–4207
  23. Tramper-Stranders G, van der Ent C, Wolfs T. Detection of Pseudomonas aeruginosa in patients with cystic fibrosis. J Cyst Fibros. 2005 Aug;4(Suppl 2):37–43
  24. Schelstraete P, Van Daele S, De Boeck K, Proesmans M, Lebecque P, Leclercq-Foucart J, et al. Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients. Eur Respir J. 2008;31:822–829

PII: S1569-1993(09)00153-2

doi: 10.1016/j.jcf.2009.11.006

Journal of Cystic Fibrosis
Volume 9, Issue 2 , Pages 99-103 , March 2010

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