Journal of Cystic Fibrosis
Volume 5, Issue 3 , Pages 177-185, August 2006

A multi-method assessment of treatment adherence for children with cystic fibrosis☆☆☆

  • Avani C. Modi

      Affiliations

    • Cincinnati Children's Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, 3333 Burnet Avenue, MLC-3015, Cincinnati, OH 45229, United States
    • Corresponding Author InformationCorresponding author. Division of Behavioral Medicine and Clinical Psychology, ML D-3015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, United States. Tel.: +1 513 636 4864; fax: +1 513 636 0084.
    • ,
  • Crystal S. Lim

      Affiliations

    • Georgia State University, Department of Psychology, P.O. Box 5010, Atlanta, GA 30302-5010, United States
    • ,
  • Nami Yu

      Affiliations

    • University of Florida, 101 South Newell Drive, Room 4160, P.O. Box 100175 HSC, Gainesville, FL 32610-0175, United States
    • ,
  • David Geller

      Affiliations

    • Nemours Children's Clinic, 83 West Columbia St., Orlando, FL 32806, United States
    • ,
  • Mary H. Wagner

      Affiliations

    • University of Florida, Department of Pediatrics, PO Box 100296, Gainesville, FL 32611, United States
    • ,
  • Alexandra L. Quittner

      Affiliations

    • Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd., Coral Gables, FL 33146-0751, United States

Received 7 December 2005; received in revised form 27 February 2006; accepted 7 March 2006.

Abstract 

Background

Adherence rates for chronic pediatric conditions are approximately 50%. The primary objective of the study was to assess rates of adherence using four different measurement methods for children with cystic fibrosis (CF).

Methods

Participants included 37 children with CF between 6 and 13 years of age and their primary caregivers. Adherence measures included parent and child self-reports, diary data, pharmacy refill history, and electronic monitors.

Results

Results suggested that rates of adherence varied by treatment component and across measurement methods. However, when examining more objective measures, rates of overall adherence were below 50% for children with CF, indicating generally poor adherence to the treatment regimen. For example, rates of adherence to enzyme medications, using electronic and diary measures, ranged from 27% to 46%.

Conclusions

The multi-method measurement approach provided unique information regarding rates of adherence for each disease condition by type of treatment component. Accurately measuring rates of treatment adherence for children with CF is an important step in developing effective interventions to influence these behaviors.

Keywords: Compliance, Pediatric, Electronic monitoring, Daily diary, Pharmacy refill

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☆ This study was funded by the Agency for Healthcare and Research Quality at the National Institutes of Health (F31 H511768) and National Institutes of Health (HL69736).

☆☆ Data presented at the North American Cystic Fibrosis Conference, Baltimore, MD in October 2005.

PII: S1569-1993(06)00034-8

doi:10.1016/j.jcf.2006.03.002

Journal of Cystic Fibrosis
Volume 5, Issue 3 , Pages 177-185, August 2006

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