Journal of Cystic Fibrosis
Volume 5, Issue 3 , Pages 165-170, August 2006

Modified shuttle test performance in hospitalized children and adolescents with cystic fibrosis

  • Narelle S. Cox

      Affiliations

    • Department of Physiotherapy, The Children's Hospital at Westmead, Australia
    • ,
  • Jennifer Follett

      Affiliations

    • Department of Physiotherapy, The Children's Hospital at Westmead, Australia
    • ,
  • Karen O. McKay

      Affiliations

    • Department of Respiratory Medicine, The Children's Hospital at Westmead, Australia
    • Discipline of Paediatrics & Child Health, The Children's Hospital at Westmead Clinical School, The University of Sydney, Westmead, NSW, Australia
    • Corresponding Author InformationCorresponding author. Department of Respiratory Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia. Tel.: +61 2 9845 3018; fax: +61 2 9845 3395.

Received 3 February 2005; received in revised form 24 February 2006; accepted 27 February 2006.

Abstract 

Background

The Modified Shuttle Test (MST) is a valid and sensitive measure of exercise capacity in adult CF patients. Recently, its validity in children has been demonstrated. The aim of this study was to demonstrate the utility of the MST as a measure of responsiveness to hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.

Methods

28 children and adolescents (40 admissions) performed a MST and lung function within 48 h of admission and discharge to hospital for administration of intravenous antibiotics. Mean age was 12.7 years and antibiotic therapy length was 14.7 days.

Results

Upon admission, the mean (S.D.) FEV1 was 63 (19)% predicted, FVC was 80 (18)% predicted, FEF25–75 43 (29)% predicted and MST distance 718 (232) m. FEV1 increased by 15% (p≤0.001), FVC by 13% (p≤0.001), FEF25–75 by 39% (p≤0.001) and MST distance by 102 m (p≤0.001). The percentage improvement in MST distance at 18% (p≤0.001) was similar to that for FEV1, but could not be predicted by the change in FEV1.

Conclusion

This study demonstrated the utility of the MST to assess the effect of hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.

Keywords: Exercise testing, Paediatrics, Exercise tolerance, Physiotherapy, Lung function, Antibiotics

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PII: S1569-1993(06)00032-4

doi:10.1016/j.jcf.2006.02.004

Journal of Cystic Fibrosis
Volume 5, Issue 3 , Pages 165-170, August 2006

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