Journal of Cystic Fibrosis
Volume 4, Issue 3 , Pages 197-201, September 2005

Acute renal failure in CF patients chronically infected by the Liverpool epidemic Pseudomonas aeruginosa strain (LES)

The Cardiothoracic Centre, Liverpool, UK

Received 20 January 2005; received in revised form 2 February 2005; accepted 17 May 2005.

Abstract 

Although acute renal failure has been described in children with CF in relation to intravenous aminoglycoside use, there are no reports in the adult CF literature. We describe 8 cases of acute renal failure in adult CF patients, all occurring during the use of intravenous aminoglycosides for the treatment of pulmonary exacerbations with an epidemic multi-resistant Pseudomonas aeruginosa strain. Potential contributory factors are discussed. These cases demonstrate another complication of infection by epidemic Pseudomonas strains in CF, and confirm the need for effective segregation policies to prevent this.

Keywords: Aminoglycoside therapy, Renal complications, Transmissible Pseudomonas aeruginosa, Cystic fibrosis

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PII: S1569-1993(05)00075-5

doi:10.1016/j.jcf.2005.05.017

Journal of Cystic Fibrosis
Volume 4, Issue 3 , Pages 197-201, September 2005

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