Journal of Cystic Fibrosis
Volume 4, Issue 3 , Pages 151-156 , September 2005

Soluble transferrin receptors and tissue oxygenation in non anaemic cystic fibrosis patients

  • Elena Christoforou

      Affiliations

    • Haematology Laboratory, “Aghia Sophia” Children's Hospital, 115 27 Athens, Greece
    • Medical Genetics, Athens University, “Aghia Sophia” Children's Hospital Athens, Greece
    • ,
  • Ioannis Papassotiriou

      Affiliations

    • Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 7467931; fax: +30 210 7467171.
    • ,
  • Christophille Skarmoutsou

      Affiliations

    • Haematology Laboratory, “Aghia Sophia” Children's Hospital, 115 27 Athens, Greece
    • ,
  • Stavros Doudounakis

      Affiliations

    • Cystic Fibrosis Unit, “Aghia Sophia” Children's Hospital, Athens, Greece
    • ,
  • Alexandra Stamoulakatou

      Affiliations

    • Haematology Laboratory, “Aghia Sophia” Children's Hospital, 115 27 Athens, Greece
    • ,
  • Emmanuel Kanavakis

      Affiliations

    • Medical Genetics, Athens University, “Aghia Sophia” Children's Hospital Athens, Greece

Received 6 August 2004 ,Accepted 10 May 2005.

References 

  1. Welsh MJ, Tsui LC, Boat TF, Beaudet AL. Metabolic and molecular basis or inherited disease. In:  Scriver CR,  Beaudet AL,  Sly WS,  Vade D editor. Cystic fibrosis. McGraw-Hill; 1994;
  2. Welsh Michael J, Smith Alan E. Cystic fibrosis. Scientific American; 1995 (Dec 1–9);
  3. Koch C, Hoiby N. Pathogenesis of cystic fibrosis. Lancet. 1993;341:1065–1069
  4. Hoiby N. Inflammation and infection in cystic fibrosis—hen or egg?. Eur Respir J. 2001;17:4–5
  5. Robinson P. Cystic fibrosis. Thorax. 2001;56:237–241
  6. Caplan A, Gross S. Haematologic and serologic studies in cystic fibrosis. J Pediatr. 1968;73:540–547
  7. Reid L, Ryland D. The pulmonary circulation in cystic fibrosis. In:  Mangos JA,  Talamo RC editor. Fundamental problems of cystic fibrosis and related diseases. New York: Intercontinental Medical Book Corporation; 1973;p. 201
  8. di Sant'Agnese P, Davis P. Cystic fibrosis in adults. Am J Med. 1979;66:121–132
  9. Wagener JS, Corrigan JJ, McNeil GC, Lemen R, Taussing LM. Ferrokinetic and haemotologic studies in cystic fibrosis patients. Am J Pediatr Hematol Oncol. 1983;5:153–160
  10. Ater JL, Herbst JJ, Landaw SA, et al. Relative anemia and iron deficiency in cystic fibrosis. Pediatrics. 1983;71:810–814
  11. Vichinsky Elliott P, Pennathur-Das Rukmani, Nickerson Bruce, et al. Inadequate erythroid response to hypoxia in cystic fibrosis. J Pediatr. 1984;105:15–21
  12. Pond MN, Morton AM, Conway SP. Functional iron deficiency in adults with cystic fibrosis. Respir Med. 1996;90:409–413
  13. Erhardt P, Miller MG. Iron deficiency in cystic fibrosis. Arch Dis Child. 1987;62:185–187
  14. Zempsky WT, Rosenstein BJ, Carroll JA, et al. Effect of pancreatic enzyme supplements on iron absorption. Am J Dis Child. 1989;143:617–622
  15. Cucchiara SF, Satamaria F, Andreotti MR, et al. Mechanisms of gastro oesophageal reflux in cystic fibrosis. Arch Dis Child. 1991;66:617–622
  16. Elin RJ, Wolf SM, Finch CA. Effect of induced fever on serum iron and ferritin concentrations in man. Blood. 1997;49:147–153
  17. Reid David W, Withers Nicholas J, Francis Libby, Wilson John W, Kotsimbos Thomas C. Iron deficiency in cystic fibrosis: relationship to lung disease severity and chronic pseudomonas aeruginosa infection. Chest. 2002;121:48–54
  18. Ater Joann L, Herbst John J, et al. Relative anaemia and iron deficiency in cystic fibrosis. Pediatrics. 1983;71:810–814
  19. Van Asbeck BS, Verhoef J. Iron and host defence. Eur J Clin Microbiol. 1983;2:6–10
  20. Gabay C, Kushner I. Acute phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448–454
  21. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anaemia of chronic disease from iron deficiency. J Lab Clin Med. 1992;119:385–390
  22. Nielsen OJ, Andersen LS, Hansen NE, Hansen TM. Serum transferrin receptor in anaemic patients with rheumatoid arthritis. Scand J Clin Lab Invest. 1994;54:75–82
  23. Petterson T, Kivivuori Sm, Slimes SA. Is serum transferring receptor useful for detecting iron-deficiency in anaemic patients with chronic inflammatory diseases?. Br J Rheumatol. 1994;33:740–744
  24. Punnonen K, Irjala K, Rajamaki A. Serrum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052–1057
  25. Suominen P, Punnonen K, Rajamaki A, Irjala K. Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem. 1997;43:1642–1646
  26. Iacopetta BJ, Morgan Eh, Yeoh GCT. Transferrin receptors and iron uptake during erythroid cell development. BBA. 1982;687:204–210
  27. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med. 1999;44:63–74
  28. Müllner EW, Neupert B, Kuhn LC. A specific mRNA binding factor regulates the iron dependent stability of cytoplasmic transferrin receptor mRNA. Cell. 1989;58:373–382
  29. Casey Jl, Hentze MW. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science. 1988;240:924–928
  30. Ponka Prem, Chun Nam Lok . The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999;31:1111–1137
  31. Feelders Richard A, Kuiper-Kramer Ellen PA, van Elijk Henk G. Structure, function and clinical significance of transferrin receptors. Clin Chem Lab Med. 1999;37:1–10
  32. Hutchinson RE, Davey FR. In:  Henry JB editors. Hematopoiesis, clinical diagnosis and management by laboratory methods. 19th edition. WB Saunders; 1996;
  33. Mavromichalis J, Zannos-Mariolea L, Nicolaidou M, Georgatou Ph, Dentaki-Slovaki K, Matsaniotis N. Haematologigal findings in Greek children with cystic fibrosis. Helv Paediatr Acta. 1974;29:151–155
  34. Rosenthal A, Khaw KT, Scwachman H. Haemoglobin–oxygen equilibrium in cystic fibrosis. Pediatrics. 1997;59:919–926

PII: S1569-1993(05)00071-8

doi: 10.1016/j.jcf.2005.05.013

Journal of Cystic Fibrosis
Volume 4, Issue 3 , Pages 151-156 , September 2005

Article Tools

* Image Usage & Resolution