Journal of Cystic Fibrosis
Volume 3, Issue 2 , Pages 93-98 , June 2004

Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults

  • J.M Courtney

      Affiliations

    • Adult Cystic Fibrosis Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, North Ireland, UK
    • Centre for Inflammation, Queens University, Belfast, UK
    • ,
  • K.E.A Dunbar

      Affiliations

    • Centre for Inflammation, Queens University, Belfast, UK
    • Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, UK
    • ,
  • A McDowell

      Affiliations

    • Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, UK
    • ,
  • J.E Moore

      Affiliations

    • Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, UK
    • ,
  • T.J Warke

      Affiliations

    • Adult Cystic Fibrosis Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, North Ireland, UK
    • Centre for Inflammation, Queens University, Belfast, UK
    • ,
  • M Stevenson

      Affiliations

    • Department of Medical Statistics, Queens University, Belfast, UK
    • ,
  • J.S Elborn

      Affiliations

    • Corresponding Author InformationCorresponding author. Adult Cystic Fibrosis Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, North Ireland, UK Tel: +44-2890-329241x3683; fax: +44-2890-263546.
    • Adult Cystic Fibrosis Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, North Ireland, UK
    • Centre for Inflammation, Queens University, Belfast, UK

Received 2 January 2003 ,Accepted 28 January 2004.

References 

  1. Burkholder WH. Sour skin, a bacterial rot of onion bulbs. Phytopathology. 1950;40:115–117
  2. Isles A, MacCluskey I, Corey M, et al.  Pseudomonas cepacia infection in cystic fibrosis; an emerging problem. J. Pediatr. 1984;104:206–210
  3. Thomassen MJ, Demko CA, Klinger JD, Stern RC. Pseudomonas cepacia colonisation among patients with cystic fibrosis. A new opportunist. Am. Rev. Respir. Dis. 1985;131:791–796
  4. McCloskey M, McCaughan J, Redmond AOB, Elborn JS. Clinical outcome after acquisition of Burkholderia cepacia in patients with cystic fibrosis. Ir. J. Med. Sci. 2001;170(1):28–31
  5. Sharma GD, Tosi MF, Stern RC, Davis PB. Progression of pulmonary disease after disappearance of Pseudomonas in cystic fibrosis. Am. J. Respir. Crit. Care Med. 1995;152:169–173
  6. Tablan OC, Chorba TL, Schidlow DV, et al.  Pseudomonas cepacia colonisation in patients with cystic fibrosis: risk factors and clinical outcome. J. Pediatr. 1985;107:382–387
  7. Govan JR, Brown PH, Maddison J, et al.  Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet. 1993;342:15–19
  8. LiPuma JJ, Dansen SE, Nielson DW, Stern RC, Stull TL. Person-to-person transmission of Pseudomonas cepacia between patients with cystic fibrosis. Lancet. 1990;336:1094–1096
  9. Aaron SD, Ferris W, Henry DA, Speert DP, Macdonald NE. Multiple combination bactericidal testing for patients with cystic fibrosis infected with Burkholderia cepacia organisms. Am. J. Respir. Crit. Care Med. 2000;161:1206–1212
  10. Coenye T, Vandamme P, Govan JR, LiPuma JJ. Taxonomy and identification of the Burkholderia cepacia complex. J. Clin. Microbiol. 2001;39:3427–3436
  11. Vermis K, Coenye T, LiPuma JJ, Mahenthiralingam E, Nelis HJ, Vandamme P. Proposal to accommodate Burkholderia cepacia genomovar VI as Burkholderia dolosa sp. nov.. Int. J. Syst. Evol. Microbiol. 2004 May;54(Pt 3):689–691
  12. Vandamme P, Holmes B, Coenye T, et al.  Burkholderia cenocepacia sp. nov.—a new twist to an old story. Res. Microbiol. 2003;154(2):91–96
  13. McDowell A, Mahenthiralingam E, Moore JE, et al.  PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients. J. Clin. Microbiol. 2001;39:4247–4255
  14. LiPuma JJ, Dylaney BJ, McMenamin JD, et al.  Development of rRNA-based PCR assays for identification of Burkholderia cepacia complex isolates recovered from cystic fibrosis patients. J. Clin. Microbiol. 1999;37:3167–3170
  15. Mahenthiralingam E, Bischof J, Byrne SK, et al.  DNA-based diagnostic approaches for investigation of Burkholderia cepacia complex, B. vietnamiensis, B. stabilis and B. cepacia genomovars I and III. J. Clin. Microbiol. 2000;38:3165–3173
  16. Mahenthiralingam E, Simpson DA, Speert DP. Identification and characterization of a novel DNA marker associated with epidemic Burkholderia cepacia strains recovered from patients with cystic fibrosis. J. Clin. Microbiol. 1997;35(4):808–816
  17. Crowley D, Daly M, Lucey B, et al.  Molecular epidemiology of cystic fibrosis-linked Burkholderia cepacia complex isolated from three national referral centres in Ireland. J. Appl. Microbiol. 2002;92(5):992–1004
  18. Mahenthiralingam E, Campbell M, Foster J, Lam J, Speert D. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J. Clin. Microbiol. 1996;34:1129–1135
  19. Livesly MA, Baxter IA, Lambert PA, et al.  Subspecific differentiation of Burkholderia cepacia isolates in cystic fibrosis. J. Med. Microbiol. 1998;47(11):999–1006
  20. Clode FE, Kaufmann ME, Malnick H, Pitt TL. Distribution of genes encoding putative transmissibility factors among epidemic and nonepidemic strains of Burkholderia cepacia from cystic fibrosis patients in the United Kingdom. J. Clin. Microbiol. 2000;38:1763–1766
  21. Frangolias DD, Mahenthiralingam E, Rae S, et al.  Burkholderia cepacia infection in cystic fibrosis: variable disease course. Am. J. Respir. Crit. Care Med. 1999;160(5 Part1):1572–1577
  22. Fitzgerald DA, Cooper DM, Paul M, et al.  Burkholderia cepacia in cystic fibrosis: Novel Australian cluster strain without accelerated respiratory deterioration. J. Paediatr. Child Health. 2001;37:130–136
  23. Mahenthiralingam E, Vandamme P, Campbell ME, et al.  Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of genomovar III can replace Burkholderia multivorans. Clin. Infect Dis. 2001;33:1469–1475
  24. Aris RM, Gilligan PH, Neuringer IP, Gott KR, Rea J, Yankaskas JR. The effects of panresistant bacteria in cystic fibrosis patients on lung transplant outcome. Am. J. Respir. Crit. Care Med. 1997;155(5):1699–1704
  25. Egan TM, Detterbeck FC, Mill MR, et al.  Long-term results of lung transplantation for cystic fibrosis. Eur. J. Cardiothorac. Surg. 2002;22(4):602–609
  26. De Soyza A, McDowell A, Archer L, et al.  Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis. Lancet. 2001;35:1780–1781
  27. Schwab U, Leigh M, Ribeiro C, et al.  Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia. Infect. Immun. 2002;70(8):4547–4555
  28. Whiteford ML, Wilkinson JD, McColl JH, et al.  Outcome of Burkholderia (Pseudomonas) cepacia colonisation in children with cystic fibrosis following a hospital outbreak. Thorax. 1995;50:1194–1198
  29. Vandamme P, Holmes B, Vancanneyt M, et al.  Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients: proposal of B. multivorans sp. nov. Int. J. Syst. Bacteriol. 1997;47:1188–2000
  30. Hutchison ML, Govan JRW. Pathogenicity of microbes associated with cystic fibrosis. Microbes Infect. 1999;1:1005–1014
  31. Sajjan US, Sun L, Goldstein R, Forstner JF. Cable (cbl) type II pili of cystic fibrosis-associated Burkholderia (Pseudomonas) cepacia: nucleotide sequence of the cblA major subunit pilin gene and novel morphology of the assembled appendage fibres. Bacteriology. 1995;177:1030–1038
  32. Sun L, Jiang R-Z, Steinbach S, et al.  The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing cystic fibrosis centre epidemics in North America and Britain. Nat. Med. 1995;1:661–666
  33. Mahenthiralingam E, Baldwin A, Vandamme P. Burkholderia cepacia complex infection in patients with cystic fibrosis. J. Med. Microbiol. 2002;51(7):533–538
  34. Garred P, Pressler T, Madsen HO, et al.  Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J. Clin. Invest. 1999;104(4):431–437
  35. Sheely DB, Spilker T, Gracely EJ, Coenye T, Vandamme P, LiPuma JJ. Utility of commercial systems for identification of Burkholderia cepacia complex from cystic fibrosis sputum culture. J. Clin. Microbiol. 2000;38:3112–3115
  36. VanPelt P, Verduin CM, Goessens WHF, et al.  Identification of Burkholderia spp. In the clinical microbiology laboratory: a comparison of conventional and molecular methods. J. Clin. Microbiol. 1999;37:2158–2164

☆ Grant support—Research and Development Project Grant, North–South Co-operation.

PII: S1569-1993(04)00032-3

doi: 10.1016/j.jcf.2004.01.005

Journal of Cystic Fibrosis
Volume 3, Issue 2 , Pages 93-98 , June 2004

Article Tools

* Image Usage & Resolution