Journal of Cystic Fibrosis
Volume 2, Issue 1 , Pages 1-7 , March 2003

Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects

  • José Luis Lezana

      Affiliations

    • Department of Paediatric Pulmonology and Respiratory Physiology, Hospital Infantil de México, Dr. Márquez 162, Col. Doctores, CP 06720 Mexico DF, Mexico
    • Asociación Mexicana de Fibrosis Quı́stica AC, Mexico DF, Mexico
    • Corresponding Author InformationCorresponding author. Tel.: +52-55-5228-9917x1228; fax: +52-55-5761-7057
    • ,
  • Mario H. Vargas

      Affiliations

    • Medical Research Unit in Clinical Epidemiology, Hospital de Pediatrı́a, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico DF, Mexico
    • ,
  • José Karam-Bechara

      Affiliations

    • Department of Paediatric Pulmonology and Respiratory Physiology, Hospital Infantil de México, Dr. Márquez 162, Col. Doctores, CP 06720 Mexico DF, Mexico
    • ,
  • Ruth S. Aldana

      Affiliations

    • Department of Paediatric Pulmonology and Respiratory Physiology, Hospital Infantil de México, Dr. Márquez 162, Col. Doctores, CP 06720 Mexico DF, Mexico
    • ,
  • Marı́a E.Y. Furuya

      Affiliations

    • Division of Medical Specialities, Hospital de Pediatrı́a, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico DF, Mexico

References 

  1. Rosenstein BJ, Cutting GR. The diagnosis of cystic fibrosis: a consensus statement. J Pediatr. 1998;132:589–595
  2. Shwachman H, Mahmoodian A, Neff RK. The sweat test: sodium and chloride values. J Pediatr. 1981;98:576–578
  3. Gibson LE, Cooke RE. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. 1959;23:545–549
  4. National Committee for Clinical Laboratory Standards. Sweat testing: sample collection and quantitative analysis; approved guideline, Publication No C34-A2. 2nd ed. Wayne, PA: NCCLS; 2000;
  5. Cystic Fibrosis Foundation, Center Director Committee. Update 1. Bethesda: CFF, 1993
  6. Denning CR, Huang NN, Cuasay LR, et al.  Cooperative study comparing three methods of performing sweat test to diagnose cystic fibrosis. Pediatrics. 1980;66:752–757
  7. Carter EP, Barrett AD, Heeley AF, Kuzemko JA. Improved sweat test method for the diagnosis of cystic fibrosis. Arch Dis Child. 1984;59:919–922
  8. Webster HL, Barlow WK. New approach to cystic fibrosis diagnosis by use of an improved sweat-induction/collection system and osmometry. Clin Chem. 1981;27:385–387
  9. Hammond KB, Turcios NL, Gibson LE. Clinical evaluation of the macroduct sweat collection system and conductivity analyzer in the diagnosis of cystic fibrosis. J Pediatr. 1994;124:255–260
  10. Sanchez ID, Perret CP, Kolbach MR, Schwerter MTM, Quiroga TG. Comparacion entre dos metodos de determinacion del test del sudor en el diagnostico de fibrosis quistica. Revista Chilena de Pediatria. 1999;70:281–287
  11. Heeley ME, Woolf DA, Heeley AF. Indirect measurements of sweat electrolyte concentration in the laboratory diagnosis of cystic fibrosis. Arch Dis Child. 2000;82:420–424
  12. LeGrys VA. Sweat analysis proficiency testing for cystic fibrosis. Pediatr Pulmonol. 2000;30:476–480
  13. Van der Merwe D, Ubbink JB, Delport R, Becker P, Dhatt GS, Vermaak H. Biological variation in sweat sodium chloride conductivity. Ann Clin Biochem. 2002;39:39–43
  14. Shwachman H, Mahmoodian A. Pilocarpine iontophoresis sweat testing results of seven years’ experience. In:  Rossi E,  Stoll E editor. Modern problems in pediatrics. Basel: Karger; 1967;p. 158–182
  15. Slegers JFG. A mathematical approach to the two-step reabsorption hypothesis. In:  Rossi E,  Stoll E editor. Modern problems in pediatrics. Basel: Karger; 1967;p. 74–87
  16. Sweat Chek® conductivity analyser product sheet. Available at URL http://www.wescor.com/biomedical/html/sweat-chek.html (accessed on 25 January 2002)

PII: S1569-1993(02)00146-7

doi: 10.1016/S1569-1993(02)00146-7

Journal of Cystic Fibrosis
Volume 2, Issue 1 , Pages 1-7 , March 2003

Article Tools

* Image Usage & Resolution